Irene Sciences
Contract Research Organization specializing in target expression analysis in human nervous tissues.
Over 90% of pain therapeutics fail clinical trials. These failures likely stem from fundamental differences in the sensory systems between preclinical rodent models and humans. To ensure the highest likelihood of therapeutic success in humans, we investigate the expression of pain therapeutic targets at the mRNA and protein level in human nervous tissues.
Our Services
Human Nervous Tissues
Dorsal root ganglion
Spinal Cord
Femoral nerve
*Procured from organ donors and pre-screened for morphological integrity and RNA quality.
*Available: Comparisons between donors with pain (diabetic neuropathy) and non-diabetic controls.
Assays
RNAscope in situ hybridization
Immunohistochemistry
*Coming soon!* Calcium imaging on cultured human sensory neurons!
Reporting
Images are acquired on a confocal microscope, analyzed for target expression in relation to known population markers, graphed, and shared as a report.
*All experiments are completed by skilled experts.
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